In all the articles studied, it was observed that the efficacy and usefulness of the different drugs in combating CRS were based on their ability to reduce the levels of the pro-inflammatory cytokines IL-1, IL-2R, IL-6, IL-8, IL-10, IL-18, TNF-α, and MCP-1 [35,36,37,38,39,40,41,42,43,44]. This evidence concerns the gene IL18 and congenital rubella syndrome.