IL6 and COVID-19: Previous reports reveal that individuals carrying the risk alleles of SERPINA1 (rs17580 (A) and rs28929474 (T)) have low levels of circulating A1AT, increasing the risk of SARS-CoV-2 infection in the Caucasian population [16]; however, in severe COVID-19, increased levels of A1AT have been observed along with other pro-inflammatory proteins, such as IL-10 and IL-6, suggesting that in severe COVID-19 cases, A1AT contributes to the appearance of a different inflammatory phenotype that could be associated with alterations in immunometabolism [17].