A novel bsAb, linking the tumor-reactive Vγ9Vδ2 T Cell Receptor (TCR) to a CD3-binding moiety, has been tested in a 3D bone marrow niche model, consisting of stromal cells, endothelial cells and MM cell lines or primary CD138+ MM cells embedded in a matrigel layer. This evidence concerns the gene SDC1 and Miyoshi myopathy.