TREM2 and Alzheimer disease: Using genome-wide RNA sequencing and multiphoton microscopy, we further identified metabolically deficient microglia in 5XFAD mice and found that exposure to Aβ triggered acute microglia inflammation with metabolic reprogramming from OXPHOS to glycolysis, following the discovery by Wang Y et al. in a 5XFAD mouse, an AD mouse model, that Aβ affected microglia activation through the receptor TREM2 [70,82].