Using a rat model for PTSD in an inhibitory avoidance apparatus, wherein rats are exposed to a single severe foot shock followed by exposure to contextual reminders, we found that acute administration of the FAAH inhibitor URB597 or the CB1/CB2 receptor agonist WIN55,212-2 after shock exposure prevented anxiety- and depression-like behaviors [3,15,16,17]. Here, CNR1 is linked to post-traumatic stress disorder.