However, the PFC of postmortem brains of major depressive disorder patients shows reduced mGluR5 protein expression [34]; in rodents, an essential role for mGluR5 in the NAc was found in promoting stress resilience, suggesting that a deficit in mGluR5-mediated signaling in this region may represent an endophenotype for stress-induced depression [35]. Here, GRM5 is linked to major depressive disorder.