We confirmed these findings also with the dimeric and water-soluble compound VitD-dgVDBP, partially because the dimeric compound is able to induce apoptosis directly measured by caspase-3, caspase-9, and cytochrome-c activity on prostatic cancer cells, as well as over the macrophage-stimulating phagocytose of several cytotoxic cells, including dendritic cells, natural killer cells, and macrophages together. This evidence concerns the gene CASP3 and Familial prostate cancer.