APOE and Alzheimer disease: However, the AUC of AD pathogenic genes was only approximately 0.65 (Sig Genes AUC: 0.646, Sig~APOE AUC: 0.659; DeLong’s test, p = 0.01/0.03), and DEGs had a minimum AUC of 0.561, which was significantly lower than that of the hub genes (DeLong’s test, p = 4 × 10−4) (Figure 4B).