Among these mitochondrion-relevant gene-enriched modules, six were selected for subsequent analyses and showed the strongest associations with AD-related traits (lightsteelblue1-MMSE/APOE2, pink-ABETA, thistle2-PTAU, violet-AGE, darkgreen-DX, and cyan-APOE4) (Figure 3D and Table S9). The gene discussed is APOE; the disease is Alzheimer disease.