ROC curves showed that the AUC of hub genes (Hub Genes AUC: 0.623) was significantly higher than that of AD pathogenic genes and AD pathogenic genes excluding APOE (Sig Genes AUC: 0.541, Sig~APOE AUC: 0.528; DeLong’s test, p = 0.02/0.008) (Figure 4A). This evidence concerns the gene APOE and Alzheimer disease.