The top 10 hub genes were RTN3, RASSF2, TCL1A, BCL11A, RANBP10, REPS2, VCAN, TMCC3, EPB41, and NEDD4L, which may play critical roles in the pathologies of AD through interaction with mitochondrial genes or participation in mitochondrion-related biological processes. This evidence concerns the gene EPB41 and Alzheimer disease.