The top 10 hub genes were RTN3, RASSF2, TCL1A, BCL11A, RANBP10, REPS2, VCAN, TMCC3, EPB41, and NEDD4L, which may play critical roles in the pathologies of AD through interaction with mitochondrial genes or participation in mitochondrion-related biological processes. The gene discussed is RTN3; the disease is Alzheimer disease.