Five MT-SNPs (m.114C > T, m.295C > T, m.310C > T, m.462C > T, m.3394T > C) are related to a variety of diseases, such as schizophrenia, bipolar disorder, low VO2max response, glaucoma, and Leber hereditary optic neuropathy (LHON).In particular, MT-ND1 (m.3394T > C, OR = 2.026, p = 0.034), MT-CO1(m.6371T > C, OR = 2.380, p = 0.015) and MT- ND5 (m.13966A > G, OR = 2.211, p = 0.019) are strikingly elevated in circulating extracellular vesicles (Evs) of MCI and AD patients relative to CN Evs. This evidence concerns the gene MT-ND5 and bipolar disorder.