Subsequently, correlations between different modules and AD-related traits were evaluated by calculating the module significance for each module-trait correlation (Mini-mental State Examination (MMSE), ABETA, TAU, PTAU, AGE, PTETHCAT (ethnicity), PTGENDER (sex), PTRACCAT (race), DIAGNOSIS (CN, MCI, AD), DX (no dementia, AD), APOE2, APOE4). This evidence concerns the gene APOE and dementia.