APOE and Alzheimer disease: Subsequently, correlations between different modules and AD-related traits were evaluated by calculating the module significance for each module-trait correlation (Mini-mental State Examination (MMSE), ABETA, TAU, PTAU, AGE, PTETHCAT (ethnicity), PTGENDER (sex), PTRACCAT (race), DIAGNOSIS (CN, MCI, AD), DX (no dementia, AD), APOE2, APOE4).