Based on the above findings, we selected for further investigation the six modules that had the strongest association with AD-related traits and that were simultaneously enriched by mitochondrion-related genes (lightsteelblue1-MMSE/APOE2, pink-ABETA, thistle2-PTAU, violet-AGE, darkgreen-DX, and cyan-APOE4). The gene discussed is APOE; the disease is Alzheimer disease.