Studies have shown that the expression of RNF2 in prostate cancer tissues is higher than that in benign prostatic hyperplasia (BPH) tissues, and the knockdown of RNF2 in prostate cancer cells leads to cell cycle arrest, increased apoptosis, and the inhibition of cell proliferation and limits the tumor growth of xenograft models [153]. This evidence concerns the gene RNF2 and Familial prostate cancer.