Two metabolites, stearic acid and linoleic acid had the adequate discriminatory capacity to separate pSS patients from HCs and correlated with clinical parameters, such as C-Reactive Protein (CRP), ESR, IgG, anti-Ro/SSA, anti-La/SSB, antinuclear antibodies, IgA and rheumatoid factor. This evidence concerns the gene CALR and peeling skin syndrome.