Increased dry eye severity level and ocular surface staining correlated with increased tear cytokine levels, except for IP-10. Negative correlations between Schirmer’s test and tears IL-1ra, IL-2, IL-4, IL-8, IL-12p70, IL-17A, IFN-γ, MIP-1b, and Rantes (r = 0.26–0.61, p < 0.05). This evidence concerns the gene IL4 and Keratoconjunctivitis sicca.