However, a previous study on human explanted left ventricular heart tissue exemplified the importance of nNOS, rather than eNOS and iNOS, in the pathophysiology of ischemic heart disease [7] Additionally, nNOS-deficient mice were shown to develop pathological left ventricular remodeling and functional decline after myocardial infarction [8,9]. The gene discussed is NOS1; the disease is myocardial infarction.