GAPDH and Alzheimer disease: There is a large body of evidence documenting that in brains of AD patients, glycolytic enzymes, such as aldolase, triosephosphate isomerase, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphoglycerate mutase 1 and α-enolase, can be oxidated thus reducing glucose metabolism and consequently ATP synthesis [180].