Pratap et al. [40], in a rat model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO), demonstrated that irbesartan (IRB) and ASA combined, used as pretreatment in MCAO rats, elevated the levels of studied antioxidants, glutathione (GSH), superoxide dismutase (SOD) and catalase. This evidence concerns the gene CAT and brain ischemia.