As an upstream regulator of NRF2-mediated ROS tolerance in malignant glioma cells, the Wiskott–Aldrich syndrome protein (WASP)-interacting protein (WIP) inhibits KEAP1, which acts as an NRF2 repressor, finally leading to reduced ROS levels and unwanted glioma cell survival [253]. This evidence concerns the gene NFE2L2 and central nervous system cancer.