The negative association of NRF2 expression and glioblastoma patient survival could be later corroborated in a large cohort of The Cancer Genome Atlas (TCGA) and be linked mechanistically not only to its already described proliferation-enhancing properties but also to an invasion-stimulatory effect in the context of positive feedback between the autophagy-associated proteins SQSTM1/p62 and NRF2 [245]. This evidence concerns the gene NFE2L2 and glioblastoma.