The results obtained from more complex in vivo murine mouse models met those expectations by showing that reduced NRF2 levels, due to either direct downregulation of NRF2 or blocking its upstream activators ERK and PI3K, were associated with reduced glioma cell proliferation, enhanced apoptosis and ferroptosis, and impaired angiogenesis [239,240,241]. The gene discussed is NFE2L2; the disease is central nervous system cancer.