IL4 and asthma: Studies have proven that the pro-inflammatory proteins, inducible nitric oxide synthase (iNOS), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) play crucial roles in the pathogenesis of asthma [2], where they induce the production of T-helper (Th) 2 cytokines, especially interleukin (IL)-13, IL-5, and IL-4 [3].