The study of X. Xiang, W. Shi, Y. Fu et al. found that heat shock protein HSP90AA1 was highly expressed in the plasma of patients with HCC, which promoted the cell cycle progression and migration of HCC cells, and could serve as a potential biomarker for the progression of HCC induced by hepatitis C virus [38,39,40]. The gene discussed is HSP90AA1; the disease is hepatocellular carcinoma.