For example, activation of the PI3K-signaling pathway induces MMP2 expression in response to cytoskeletal destabilization in endothelial cells during angiogenesis whereas inhibition of PI3K by Ly-294002 reduces MMP7 expression in triple-negative breast cancer MDA-MB468 cells [94] and colorectal cancer cells [95]. Here, MMP2 is linked to colorectal cancer.