Indeed, it was predicted that miR-205 targets the MYC proto-oncogene, bHLH transcription factor (MYC), thus leading to the inhibition of AKT and cascade activation of E3 ligases, atrogin-1/muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MurF-1), the main mediators of muscle protein degradation in cachexia [110,119]. This evidence concerns the gene MYC and Cachexia.