HAS3 and breast neoplasm: Examples of such validated genes include transmembrane protein 213 (TMEM213), upregulated in cells treated with siAKT1; Cytochrome P450 Family 4 Subfamily F Member 8 (CYP4F8), Gamma-aminobutyric acid receptor subunit pi (GABRP) and osteoclast-associated immunoglobulin-like receptor (OSCAR)—upregulated in cells treated with siAKT1, etc. Consistent with these observations, we noticed that overexpression of AKT1 mRNA in breast tumors in the TCGA dataset is generally accompanied by a substantial reduction in the levels of TMEN213, VS1G1, CYP4F8, HAS3, and OSCAR (Supplementary Figure S4).