The top ten AKT1-dependent highly abundant transcripts identified in the present study—TFF1 (ENST00000291527), EEF2 (ENST00000309311), SCD (ENST00000370355), SPTSSB (ENST00000359175), KRT81 (ENST00000327741), LAPTM4A (ENST00000175091), NUCKS1 (ENST00000367142), LAPTM4B (ENST00000445593), PERP (ENST00000421351), and KRT19 (ENST00000361566)—are also found to be upregulated in human cancers, and nine of them are highly significant cancer-associated genes in breast cancer (Supplementary Table S4). Here, NUCKS1 is linked to cancer.