IL6 and Insulin resistance: Many genes expressed in adipose tissue have been reported to contain HRE, including leptin [18], vascular endothelial growth factor-A (VEGFA) [17], glucose transporter 1, GLUT1 [19], and interleukin-6 (IL-6) [4,20,21], implying that hypoxia affects critical adipose tissue features such as inflammation, insulin resistance, glucose intolerance, and angiogenesis [4,15,22,23,24].