Endogenous and exogenous proinflammatory factors, or alarmins (DAMPs), induce inflammation by interacting with PRRs, such as RAGE, TLR-4, GPCR, and EMMPRIN (also known as basigin or CD147), which is a well-known process in rheumatoid arthritis or synovial tissue damage [125]. The gene discussed is BSG; the disease is rheumatoid arthritis.