Small subsets of S100 (for example, S100A7, S100A8, S100A9, and S100A12) have been shown to be upregulated in psoriasis skin lesions, whereas transcriptomics and ELISA-based approaches indicate that S100A12 is strongly correlated with a functional disease condition [134,135] (Figure 6). This evidence concerns the gene S100B and psoriasis.