CTF1 and myocardial infarction: They have shown that CT-1 induced cardiac fibroblast proliferation, migration, and protein synthesis via mechanisms involving the Jak/STAT, MAPK and PI3K/Akt pathways, and furthermore increased the synthesis of a marker of mature collagen, procollagen-1-carboxypropeptide (PICP), implicating CT-1 as a modulator of fibroblast function and infarct scar formation and remodelling post-MI [78,79].