Previous studies have shown that shRNA-mediated knockdown of CD147 in malignant melanoma cells, followed by treatment of fibroblasts with the corresponding microvesicles and exosomes, decreased MMPs’ enzymatic activity in recipient fibroblasts, suggesting that extravesicular CD147 downregulation is associated with decreased extracellular matrix remodeling and metastasis [56]. The gene discussed is BSG; the disease is melanoma.