TARDBP and Parkinson disease: Numerous neurological illnesses and the majority of neurodegenerative diseases have been related to abnormalities in mitochondrial redox equilibrium and excessive generation of ROS [69], particularly oxitadive stress and mitochondrial dysfunction have been linked to AD and Parkinson’s disease PD [70], thus Among other factors that can induce oxidative stress are: Amyloid beta peptide (Aβ), pathogenic tau, α-synuclein, FUS, TDP-43, mutant SOD1, and mutant Huntingtin (Figure 1b).