With regards to the variables included in the CLL-IPI (IGHV-unmutated, del(17p) and/or TP53 mutations, age over 65 years and high β2-microglobulin serum levels), high β2-microglobulin levels (>3.5 mg/L), IGHV-unmutated status, and age over 65 years were associated with worse OS in the univariate analyses (Figure 2). Here, TP53 is linked to B-cell chronic lymphocytic leukemia.