Chung et al. selected 10 candidate hypermethylated genes from data collected from tumor tissue and monitored these in voided urine samples by quantitative, methylation-specific RT-PCR and identified a multigene predictive model comprised of five target genes (MYO3A, CA10, NKX6-2, DBC1 and SOX11) [29]. The gene discussed is NKX6-2; the disease is neoplasm.