At the moment, the transition of this biomarker into the routine clinical evaluation of MFS and risk-stratification is not considered to be applicable, due to the inconsistency of results of different studies in retrieving elevated TGF-β levels in MFS patients; this is possibly due to the different population size, type of FBN1 mutation underlying the clinical picture and impacting the TGF-β pathway impairment, disease severity shown by patients, and use of medication [147]. This evidence concerns the gene FBN1 and Marfan syndrome.