TP53 and Marfan syndrome: Twenty-five miRNAs, including miR-26a, miR-29, miR-143, and miR-145, were found to be downregulated, while miR-632 was upregulated in MFS/TAA in vivo; in addition, 28 upregulated and 7 downregulated genes were identified, some of them belonging to the CDH1/APC and CCNA2/TP53 signaling pathways, which the authors propose to be further tested as potential therapeutic targets to counteract the rapid progression of MFS aortopathy.