Among them, circRNA-101238 was found to be highly expressed in human thoracic aortic dissection specimens, leading to a lower expression of the downstream target miR-320a, and, in turn, to increased MMP9 expression [212], while circMARK3-miR-1273-Fgr interaction was suggested to have a certain clinical significance in human acute Stanford type A aortic dissection (AAAD) tested by RNA-seq [213]. The gene discussed is MMP9; the disease is Aortic dissection.