The neuropathological characteristics of AD are the co-presence of extracellular amyloid plaques and intraneuronal neurofibrillary tangles, due to the accumulated protein of amyloid-β (Aβ) peptides for plaques and toxic tau for tangles, and that the soluble forms of Aβ and tau work together or independently [60]. Here, MAPT is linked to Alzheimer disease.