Reduced refractoriness was also observed in the same RyR2 CPVT model using two-photon photolysis of a caged Ca2+ chelator [106] and in other models of GoF CPVT due to missense mutations (CSQ2-R33Q [107]) or knockout of CSQ2 [108]. This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.