RYR2 and catecholaminergic polymorphic ventricular tachycardia: Indeed, Borile et al. found that during beta-adrenergic stimulation in ventricular heart slices from mice harboring the CPVT-causing RyR2-R2474S heterozygous missense mutation, cells surrounding those that exhibited DADs also had a greater probability of Ca2+ waves occurring almost synchronously [118].