By leveraging our previous RNA-seq analysis [6] and a more recent aptamer-based targeted approach [25], we observed, for the first time, that loss of sacsin affects neuroinflammation, synaptogenesis, and engulfment of cells, thereby demonstrating the feasibility of multi-dimensional integration of omics data in a rare human condition, an approach familiar more to cancer biology than neurodegeneration. The gene discussed is SACS; the disease is cancer.