Apart from its canonical roles in protein folding and calcium homeostasis, CALR also performs roles in neuronal plasticity, synaptic regulation, regulation of gene and protein expression, apoptotic susceptibility, and phagocytosis detrimental to several neurological disorders such as ischemic stroke [46,47,48,49], AD [50], PD [51,52], psychiatric disorders [53,54,55], and ALS [56,57]. This evidence concerns the gene CALR and ischemic stroke.