For these cases, the methylation classification (MNP v11b4) could not predict a confident methylation class, whereas the MNP Classifier version 12.5 in two cases predicted new tumour entities; one was classified as a neuroepithelial tumour with PATZ1 fusion and the other one as a high grade neuroepithelial tumour with PLAG‐family amplification, which had relapsed three times despite intense treatment. This evidence concerns the gene PATZ1 and neoplasm.