As shown in Figure 4c, the top 10 terms of pathways included, protein digestion and absorption, extracellular matrix (ECM)-receptor interaction, AGE-RAGE signaling pathway in diabetic complications, focal adhesion, amoebiasis, platelet activation, relaxin signaling pathway, human papillomavirus infection, PI3K-Akt signaling pathway and proteoglycans in cancer. The gene discussed is RENBP; the disease is amebiasis.