NR1H4 and cardiac hypertrophy: Additionally, in a BA-overload mouse model in which Fxr (farnesoid X receptor) and Shp (small heterodimer partner), two critical nuclear receptors responsible for maintaining bile acid homeostasis, are deleted, Desai et al. showed that the double knockout mutants (DKO) display cardiac hypertrophy, bradycardia and exercise intolerance[104].