Although PPARs are mainly known for their roles in modulating lipid metabolism, PPARγ and PPARδ also have anti-inflammatory actions on macrophages, which may contribute to the potential clinical benefit in NASH (Gallardo-Soler et al., 2008; Odegaard et al., 2007; Gordon, 2003). Here, PPARD is linked to metabolic dysfunction-associated steatohepatitis.