To discover more host factors involved in symptoms development caused by infection of CMV or CMV mutants, gene classification and function enrichment were performed with DEGs regulated in Col-CMV specifically (Col-CMV-sp) and concurrently mediated in dcl2/4-CMV, dcl2/4-Δ2b, and dcl2/4-2aTΔ2b (dcl2/4-all). Here, TFF2 is linked to infection.