The median age of advanced HIV-positive patients coinfected with COVID-19 was 57 years old (IQR, 53–62), 76% male; the HIV transmission occurred mainly by unprotected sex, and the median HIV duration of infection was 18 years (15–29) with a nadir of CD4 of 57/mmc (23–100) and a current CD4 count of 348 (186–565). This evidence concerns the gene CD4 and COVID-19.