In mouse models of IAV, most studies have examined the impact of intravenous (i.v.)pre-treatment of inbred C57BL/6 or Balb/c mouse strains with one or more doses of RIG-I agonist prior to IAV infection [8,9,10], often with subsequent i.v. doses at the time of and/or at various times after experimental infection. The gene discussed is RIGI; the disease is infection.