Accordingly, to refine the understanding of the role of the hnRNP I protein in viral transcription and replication, we examined the RNA synthesis profiles of wild-type SINV and the hnRNP I interaction-deficient viruses during infections of HEK293 cells either mock-transfected or transfected with an hnRNP ITAT expression plasmid. This evidence concerns the gene PTBP1 and infection.