ACE2 and viral infectious disease: Although 293T-ACE2 and Vero E6 have been widely used to study SARS-CoV-2 entry, replication, and antiviral treatments [3,4,23], these cells are unsuitable for investigating the pathological mechanisms of the host cell’s response to virus infection as they are not derived from human lung tissue, cannot be used to assess cytopathic effects, and do not express type I interferon genes [26].