It is well-known that ICIs plays an important role in the treatment of ccRCC; we investigated whether the risk model was related to ICI-related biomarkers and discovered that high risk scores were positively correlated with a high expression of PDCD1 (p < 0.001, Figure 5B) and CTLA4 (p < 0.001, Figure 5C). This evidence concerns the gene CTLA4 and nonpapillary renal cell carcinoma.