CD8A and nonpapillary renal cell carcinoma: First, we estimated the immune cell infiltration in high-risk subgroups using seven pieces of software and found that most types of immune cells prefer to infiltrate in subgroups with high risk (Figure 6) (which was consistent with previous research results [45]), indicating that more numerous immune cells infiltrate into the tumor tissue of patients with more advanced ccRCC whether they are immune killer cells (such as CD8+ T cell) or immunosuppressive cells (such as regulatory T cell).