Mice were intranasally administrated the influenza vaccine candidate (comprised of soluble hemagglutinin (H1), neuraminidase (N1) and soluble recombinant IL-12 adjuvant), leading to increased levels of IgG2a anti-HIN1 antibody in serum, and IgG1, IgG2a, and IgA antibodies in bronchoalveolar lavage fluids compared to the antigen alone [205]. The gene discussed is CD79A; the disease is influenza.