At the same time, The Fc segment of IgG1 was added to our MUC1-Vax fusion protein to improve the efficiency of DCs in antigen uptake, processing and cross-presentation, and the efficacy of the vaccine was tested in our constructed tumor-bearing mouse models of lung and pancreatic cancer that stably expressed MUC1 and PD-L1. Here, CD274 is linked to pancreatic neoplasm.