These additional ICs include PD-1, TIM-3, TIGIT, CD96, LAG3, CD161, Siglec-7, and IRp60 and can be up-regulated or de novo expressed by NK cells in pathologic conditions [50,51,52], thus contributing to avoid exacerbated immune responses and also favoring tumor escape (Figure 1). This evidence concerns the gene TIGIT and neoplasm.