EPCAM and colorectal carcinoma: A recent preclinical study analyzed the effect of NK-92 modified with a second-generation CAR, targeting EpCAM, in the control/eradication of the CRC line HCT-8-Luc in a subcutaneous xenograft NOD/SCID mice model and demonstrated that CAR-NK-92 cells significantly reduced tumor growth compared to the control NK-92 cell line [142].