To this end, in 2019, Xiao and coworkers demonstrated that intra-peritoneal injection of short-lived PB-derived CAR-NK cells, generated by RNA electroporation with a construct coding for NKG2D extracellular domain combined to DAP12 signaling moiety (NKG2D CAR-NK), significantly reduced tumor burden and progression in xenograft mice generated with human CRC cell lines [138]. Here, KLRK1 is linked to colorectal carcinoma.