CSPG4 and central nervous system cancer: NG2/CSPG4 is a malignant marker in CNS cancers such as gliomas, the most common and malignant cancer in the CNS [28], and it is closely related to poor prognoses as it promotes cancer cell proliferation and motility via its binding to growth factors (bFGF and PDGF-AA) [24], MMPs [29], ECM-collagen IV [30], and integrins [31], which involves these binding partners in an oncogenic transformation.