For example, in regard to vascular mural progenitor cells, NG2/CSPG4 is expressed on heart cardiomyocytes in large vessels, specifically smooth muscle cells (SMAs) [44], and on PCs in the microvasculature [45], making it even more meaningful for heart disease [46] than it has been in studies on the CNS. This evidence concerns the gene CSPG4 and heart disorder.