CSPG4 and lung cancer: Based on the finding that in the developing CNS, ECs are guided by migrating PCs during the organization of the growing vessel wall [61] and on experimental evidence showing that NG2/CSPG4-expressing PCs are more abundant than MSCs, we concluded that NG2/CSPG4-expressing MSC-like PCs become progressively upregulated with increasing malignancy in solid organ cancers, such as lung cancer [62], so it seems likely that NG2/CSPG4-expressing PCs in solid organ cancers are relatively closely related to angiogenesis [63] and metastasis [64,65].