The analysis of the metabolic transcriptional network via RNA-seq and real-time RT-qPCR revealed that metabolic pathways in autoimmune diseases are under the control of relevant transcription factors, such as Nr2f1, Nr0b1, Esrra, Esrrb, and Essrg, which regulate T cell metabolism and subsequent pro-inflammatory T cell function under modulation of estrogen-related receptor alpha [63,64]. The gene discussed is ESRRA; the disease is autoimmune disease.