AGL and obesity due to melanocortin 4 receptor deficiency: Although MAT is much less reported in studies of obesity-related diseases than total and epididymal adipose tissue, it is particularly important in the pathophysiology of MS because it is part of the visceral adipose tissue, which is directly involved in the exposure of hepatocytes to toxic metabolites contained in adipocytes, such as TG, AGL, and inflammatory cytokines, which promote the state of IR and the inflammation characteristic of MS [26].