BPD triggers, including excessive mechanical stretch and hyperoxia, downregulate PPARγ signaling and upregulate the transforming growth factor (TGF)-β/Wnt pathway, which promotes excessive mesenchymal transdifferentiation into the myofibroblast phenotype, eventually leading to an abnormal lung injury/repair process characterized by reduced alveolarization and impaired angiogenesis [9,10,11,12]. The gene discussed is PPARG; the disease is bronchopulmonary dysplasia.