SLCO1A2 and Stroke: It is striking that statins and memantine, drugs that have shown varying degrees of success in stroke, are substrates for uptake transporters that are expressed at the human brain microvascular endothelium (i.e., OATP1A2 for statins; OCT1/OCT2 for memantine) while other compounds (i.e., disufenton sodium) that are not transported at the BBB have failed in the clinic [98].