TF and glioblastoma: Using the amino group as a handle for conjugation we then conjugated two chalcones (3e, 3f) to transferrin tethered C-dots via the amide linkage and demonstrated that this C-dot DDS was up to 100-fold more efficacious than the free chalcone in our GSC lines and in non-stem GBM cell lines (U87 and SJGBM2).