For instance, it was demonstrated that the mRNA could act as a sponge, by recruiting and so neutralizing the other regulatory elements (mostly microRNAs) critical for the maintenance of normal function in the cell, as reported for the MYCN mRNA to the let-7 microRNA [14,15]; therefore, if the drug acts only at the level of the protein, this oncogenic effect would remain, while when the drug acts at the mRNA level, it has the double advantage of blocking the translation into protein and blocking the specific pro-tumor activities of the mRNA. This evidence concerns the gene MYCN and neoplasm.