After intratumoral (IT) injection, these STING-activating polymersomes (STING-NPs) have increased the gene expression levels of inflammatory cytokines (interferon-β1, CXCL9 and CXCL10) in harvested tumor cells and shown remarkable uptake by NK cells, DCs and macrophages in TME and draining lymph nodes. This evidence concerns the gene STING1 and neoplasm.